5000–10000 Da Oligo Sodium Hyaluronate, also known as low molecular weight hyaluronic acid oligomer, is favored in the cosmetics industry for its exceptional skin penetration, biological activity, and barrier repair capabilities. It offers benefits that go beyond hydration—making it a key ingredient in anti-aging, sensitive skin, and post-procedure products.
However, improper use may result in clumping, instability, or limited efficacy. This article provides a comprehensive usage guide and solves common issues encountered by formulators and contract manufacturers.
Molecular size advantage: Small enough to reach deeper epidermal layers
Active performance: Supports collagen synthesis and fibroblast activity
Gentle: Suitable for post-procedure skin and sensitive formulations
Versatile: Compatible with serums, ampoules, sheet masks, creams
| Parameter | Specification |
|---|---|
| Inclusion Rate | 0.05% – 0.5% |
| Solvent | Deionized water (room temp, <40°C) |
| Solubility | Full water solubility (with gentle stirring) |
| pH Compatibility | 4.0 – 7.0 |
| Phase Addition | Cool-down phase (<40°C) |
| Storage | Cool, dry place; airtight container |
Problem: Fast addition leads to powder sticking and incomplete hydration.
Solution:
Pre-mix the powder with glycerin or 1,3-propanediol before adding water.
Add slowly under medium-speed stirring. Allow full hydration (15–30 minutes).
Problem: Loss of efficacy or viscosity change in acidic/alkaline systems.
Solution:
Add during the cool-down phase (≤40°C).
Maintain formulation pH between 4.5–6.5.
Problem: Incompatibility with certain preservatives or actives.
Solution:
Avoid mixing with strong oxidizers or cationic surfactants.
Run compatibility tests, especially with vitamin C derivatives or AHAs.
Problem: Low concentration or improper application method.
Solution:
Ensure minimum usage at 0.1% for noticeable results.
Use in combination with peptides or niacinamide for synergistic anti-aging benefits.
Problem: Powder becomes sticky or degrades when exposed to humidity.
Solution:
Store in an airtight aluminum foil bag.
Use desiccants and avoid long exposure to air during weighing.
Hydrating facial serums
Post-treatment recovery creams
Microneedling repair solutions
Sensitive skin masks or ampoules
Anti-wrinkle essence with peptides
Pair with high molecular weight HA for layered hydration.
Use airless packaging for better product protection.
Conduct accelerated stability testing at 40°C/75% RH for 3 months.
Optimize texture with non-ionic thickeners (e.g., xanthan gum, hydroxyethylcellulose).
Combine with ceramides or panthenol for barrier-boosting systems.
RUNXIN Biotech offers premium-grade Oligo Sodium Hyaluronate with full technical documentation, COA, and regulatory support. Whether you’re developing an innovative skincare product or scaling up manufacturing, our team is ready to support your formulation journey.
Request samples or get a quote today — let’s make your formulation science-backed and market-ready.