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Application of food grade sodium hyaluronate:
HA is used in health food and is often used in combination with collagen, vitamins, chondroitin sulfate, glucosamine and other ingredients. Tablets, capsules, and oral liquids are commonly used dosage forms. On January 7, 2021, the National Health Commission issued an official announcement, approving sodium hyaluronate (ie, hyaluronic acid, HA) as a new food raw material, which can be used in ordinary food additions. The scope of use is milk and dairy products: 0.2g/kg, beverages (liquid beverages ≤ 50mL packaging: 2.0g/kg, 51mL-500mL packaging: 0.2g/kg. Solid beverages are converted according to the volume of liquid after reconstitution) wine ( 1.0g/kg), cocoa products, chocolate and chocolate products (including cocoa butter substitute chocolate and products) and candy (3.0g/kg), frozen drinks (2.0g/kg), not suitable for infants, pregnant women and lactating women , the label and instructions should indicate that it is not suitable for people, and the recommended consumption is <200mg/day.
Product Specifications
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Test items |
Sodium salt identification reaction |
Sodium Hyaluronate Content |
Molecular weight |
Transmittance |
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Test items |
PH value |
Moisture |
Ash |
Lead (as Pb) |
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Test items |
Arsenic (as As) |
Total number of colonies |
Mold and Yeast |
Salmonella |
Sodium Hyaluronate and Human Health
With the increase of age, cell metabolism slows down, and the human body's ability to synthesize hyaluronic acid gradually declines. On the one hand, it is manifested that the collagen fibers and elastic fibers in the skin do not have sufficient moisture, resulting in loss of skin elasticity and wrinkles. On the other hand, the reduction of hyaluronic acid in synovial fluid will weaken the protective effect of shock absorption and lubrication of articular cartilage, which will lead to joint inflammation such as joint pain and limited movement.
Oral absorption mechanism of sodium hyaluronate
The synthesis and decomposition of hyaluronic acid in the human body is a dynamic equilibrium process. It has been proved by animal and human experiments that oral hyaluronic acid can directly supplement the missing hyaluronic acid in the body, and can increase the precursor substances of hyaluronic acid synthesis in the body, and promote the synthesis of hyaluronic acid.
The curve of serum HA-time in rats by intragastric administration
Hyaluronic acid is an important component of the extracellular matrix (ECM) and plays an important role in maintaining the shape, structure and function of the skin.
Clinical efficacy validation
Shandong Runxin Biotechnology Co., Ltd.
A professional sodium hyaluronate and chondroitin sulfate manufacturer with global positioning. The company was established in 1998. It covers an area of more than 30,000 square meters and has a total investment of over 100 million yuan. It has GMP standard workshops and a professional R&D team, dedicated to hyaluronic acid...
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