Cationic Sodium Hyaluronate, a positively charged derivative of hyaluronic acid, has become a sought-after ingredient for its ability to adhere to negatively charged skin and hair, providing longer-lasting hydration, improved active delivery, and superior sensory properties. However, its charge-based behavior introduces new formulation challenges that require proper handling.
In this article, we offer a practical usage guide, highlight key formulation tips, and troubleshoot common issues that occur during development and production.
Electrostatic adhesion: Forms a longer-lasting moisturizing film by binding to the skin and hair.
Improved sensory: Leaves a soft, velvety finish.
Efficient active delivery: Enhances the retention and effect of other actives when used in toners or masks.
Dual-use: Works well in both skincare and hair care formulas.
| Parameter | Recommended Specification |
|---|---|
| Inclusion Level | 0.1% – 0.5% |
| Solubility | Fully water-soluble |
| Best pH Range | 4.5 – 6.5 |
| Add-in Phase | Cool-down phase (<40°C) |
| Storage | Dry, cool place in sealed container |
Cause: Incompatibility with anionic surfactants or acids.
Solution:
Avoid mixing with strong anionic emulsifiers (e.g. SLS, SLES).
Keep pH between 4.5 and 6.5 for optimal charge retention and solubility.
Test small batches when working with vitamin C, AHA/BHA.
Cause: Excessive dosage or poor pairing with base oils/emollients.
Solution:
Use ≤0.3% for daily-use products (e.g., toner or serum).
Balance formula with light esters or silicones to improve glide and after-feel.
Cause: High temperature or improper storage.
Solution:
Always add in the cool-down phase (<40°C).
Store in a sealed, moisture-proof container to prevent degradation.
Cause: Reactions between cationic HA and certain preservatives.
Solution:
Use compatible systems like phenoxyethanol + ethylhexylglycerin.
Avoid excessive alcohol or strong cationic/acidic compounds unless tested.
Cause: Cationic HA interacts with thickening agents.
Solution:
Test in advance with non-ionic thickeners (e.g., HEC, xanthan gum).
Avoid pairing with carbomer unless neutralized in advance.
Premium facial toners and long-lasting serums
Sheet mask essence bases with prolonged moisture lock
Post-treatment or calming lotions for irritated skin
Scalp & hair sprays with anti-frizz and repair properties
Sun care and after-sun gels with barrier-supporting effect
Pair with high molecular HA for dual-layer hydration (instant + long-term).
For scalp care, combine with niacinamide, panthenol or herbal actives.
Test charge stability under high humidity and temperature if exporting globally.
Ideal for Halal-certified, clean beauty, and minimalist formulations.
RUNXIN Biotech offers high-purity, cosmetic-grade cationic sodium hyaluronate with full documentation, technical support, and tailored molecular solutions.
Contact us today for:
✔️ Samples
✔️ Formulation advice
✔️ OEM or bulk order pricing
Let’s help you create hydrating, adhesive, and stable skincare formulas with proven efficacy.