Application Guide & Common Troubleshooting for Formulators
5000 Da Sodium Hyaluronate is a low molecular weight grade of hyaluronic acid designed to offer both surface hydration and dermal penetration. It’s widely used in cosmetic formulations for its fast absorption, skin repair support, and compatibility with sensitive skin.
However, as with any active ingredient, improper use may lead to instability, reduced efficacy, or unwanted textures. This article offers a practical usage guide, formulating tips, and solutions to common issues experienced by skincare manufacturers.
With a molecular size of ~5000 Daltons, this form of hyaluronic acid strikes the perfect balance:
Smaller than high molecular weight (HMW) HA, allowing partial penetration into the epidermis.
Larger than ultra-low (sub-1000 Da) HA, which helps retain moisture on the surface and reduce trans-epidermal water loss (TEWL).
Suitable for hydrating, repairing, and calming applications.
| Parameter | Recommended Value |
|---|---|
| Inclusion rate | 0.1% – 1.0% |
| Solvent | Purified / deionized water |
| Hydration temperature | 20–40°C (avoid high heat) |
| pH stability range | 4.0 – 7.0 |
| Phase to add | Cool-down phase (<40°C) |
Problem: Adding HA powder too quickly can cause clumps or gel balls.
Solution:
Pre-wet the powder with 10% glycerin or 1,3-propanediol before adding water.
Use a high-shear or vortex mixer to disperse evenly.
Problem: Overuse can lead to a tacky feel.
Solution:
Keep dosage within 0.3–0.6% for leave-on products.
Pair with light emollients (e.g., squalane, cyclopentasiloxane) to balance skin feel.
Problem: Sodium hyaluronate loses effectiveness if heated >50°C.
Solution:
Always add HA during the cool-down phase.
Store the raw material in a dry, cool environment.
Problem: May destabilize when mixed with strong acids or cationic preservatives.
Solution:
Formulate at a neutral pH (4.5–6.5).
Avoid high ethanol or benzalkonium chloride concentrations.
Problem: Powder appears only partially dissolved.
Solution:
Ensure gentle stirring for at least 30 minutes.
Use purified water with adjusted pH for optimal solubility.
Hydrating facial serums
Barrier repair creams for sensitive skin
Post-treatment soothing gels (after sun, microneedling)
Herbal-based calming lotions
Night repair masks or sleeping packs
5000 Da sodium hyaluronate is particularly favored in dermatology-led brands, medical skincare lines, and OEM manufacturers targeting premium hydration and skin-calming effects.
Use in combination with niacinamide, ceramides, and panthenol for full-spectrum skin barrier support.
For better synergy, layer with high molecular weight HA for dual-layer hydration.
Conduct stability tests on finished product to validate long-term viscosity and performance.
RUNXIN Biotech offers pharmaceutical-grade, cosmetic-compliant sodium hyaluronate with custom molecular weight options, full certification (ISO/GMP/Halal), and technical support for new product development.
Contact us for bulk pricing, sample requests, or customized formulation services.
Let our 28+ years of expertise elevate your skincare innovations.