Acetylated Sodium Hyaluronate
RUNXIN BIOTECH
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Amphiphilic Acetylated Sodium Hyaluronate (AcHA) is a chemically modified derivative of hyaluronic acid—a naturally occurring polysaccharide found in human connective and epithelial tissues. Through targeted acetylation technology, acetyl groups are introduced to replace select hydroxyl (-OH) groups on the hyaluronic acid backbone.
Traditional hyaluronic acid presents significant limitations in modern skincare development:
· Precipitation in oil-based formulations: Standard HA cannot remain stable in oil phases, causing texture inconsistencies
· Limited skin retention: Without lipophilic characteristics, HA molecules wash off easily, reducing efficacy
· Enzymatic degradation: Hyaluronidase enzymes in skin rapidly break down conventional HA, shortening its active lifespan
This dual-functional structure addresses common formulation challenges by anchoring more effectively to the skin surface while providing extended hydration across both aqueous and oil-based formulation systems.
The acetyl groups within AcHA act as molecular "anchors" that:
1. Increase skin affinity — Lipophilic segments adhere to the lipid components of the stratum corneum
2. Extend surface retention — Even after rinsing, the modified molecule maintains skin surface presence longer than standard HA
3. Enable cross-phase compatibility — Stable performance in water, oil, and hybrid formulations
Property | Standard Sodium Hyaluronate | Acetylated Derivative |
Skin penetration depth | Up to 50 μm | Up to 100 μm |
Hyaluronidase resistance | Baseline | 13× higher resistance |
Oil-phase compatibility | None | Stable in oil phases |
Surface retention | Moderate | Significantly extended |
Skin barrier repair | Limited | Enhanced barrier protein synthesis |
· Sustained hydration: Maintains moisture levels exceeding standard HA at 72-hour intervals
· Deeper dermal delivery: Reaches up to 100 μm into skin tissue versus 50 μm for conventional HA
· Enzyme resistance: 13× greater resistance to hyaluronidase degradation, extending active performance duration
· Barrier enhancement: Promotes barrier protein synthesis, improving cell barrier function and skin resilience
This ingredient offers a non-sticky, lightweight sensory profile compared to conventional HA. This makes it particularly suitable for premium formulations where texture excellence is as critical as efficacy.
Parameter | Specification |
Appearance | White to off-white powder or particles |
CAS Number | 158254-23-0 |
INCI Name | Sodium Acetylated Hyaluronate |
Acetyl Content | 23.0%–29.0% |
Molecular Weight | 20,000–50,000 Da (customizable) |
pH Value (0.5% solution) | 5.0–7.0 |
Light Transmittance (0.5%) | A600nm ≥ 99.0% |
Loss on Drying | ≤ 10.0% |
Burning Residue | 11.0%–16.0% |
Heavy Metals | ≤ 20 ppm |
Nitrogen Content | 2.0%–3.0% |
Intrinsic Viscosity | 0.05–0.25 m³/kg |
Test Item | Specification |
Total Plate Count | ≤ 100 CFU/g |
Mold & Yeast | ≤ 50 CFU/g |
Escherichia coli | Negative |
Staphylococcus aureus | Negative |
· Powder (standard)
· Particles (for specific formulation requirements)
· Custom specifications available upon request (molecular weight, acetylation degree, particle size)
Store in airtight containers at 2–10°C. Shelf life: 2 years when properly stored.
Application Type | Recommended Concentration |
Skincare serums | 0.1%–0.5% |
Moisturizing creams | 0.1%–0.3% |
Facial masks | 0.05%–0.2% |
Sunscreen products | 0.1%–0.5% |
Oil-based formulations | 0.1%–1.0% |
Medical dressings | 0.1%–2.0% |
Water-Based Systems
· Hydrating serums and essences
· Toners and lotions
· Gel formulations
· Sheet masks
Oil-Based Systems
· Facial oils
· Cleansing oils
· Oil-in-water emulsions
· Sunscreen emulsions
Advanced Formulations
· Dual-phase (water + oil) products
· Medical-grade dressings
· Premium anti-aging treatments
· Sensitive skin care lines
For Water-Based Formulas:
Dissolve in the aqueous phase during manufacturing. Heat to 40–60°C for optimal dispersion. Compatible with most water-soluble ingredients.
For Oil-Based Formulas:
Blend directly with the oil phase. The amphiphilic nature ensures uniform distribution without precipitation or activity loss.
Compatibility Notes:
AcHA is compatible with common cosmetic ingredients including humectants, emollients, surfactants, and most active compounds. For formulations containing strong acids or bases, add during the cooling phase.
Shandong Runxin Biotechnology Co., Ltd. has dedicated nearly three decades to hyaluronic acid research, development, and manufacturing. Our focused expertise in HA derivatives enables us to deliver:
· Consistent quality: Rigorous batch-to-batch standardization
· Technical depth: Deep understanding of molecular modification processes
· Application support: Formulation guidance from our R&D team
· Annual capacity: Sufficient supply for both pilot-scale and industrial production volumes
· Flexible MOQ: Options from small R&D quantities to full container orders
· Custom specifications: Tailored molecular weight, particle size, and acetylation degree to match your formulation requirements
· Lead time: 3–7 working days for standard specifications
· Sample service: Free samples available (shipping charged) for quality evaluation
· Documentation: COA, SDS/MSDS, and TDS available for all products
Our team provides:
· Formulation troubleshooting support
· Regulatory documentation assistance
· Custom development for specific applications
· Scale-up guidance from lab to production
Runxin Biotech maintains comprehensive quality management systems certified to international standards:
Certification | Scope |
ISO 13485 | Medical device quality management |
CE | European market compliance |
FDA | US regulatory compliance |
cGMP | Good manufacturing practice |
ISO 9001 | Quality management systems |
Halal | Islamic certification |
REACH | EU chemical regulation |
COSMOS | Organic/natural cosmetic certification |
Every batch undergoes complete quality inspection with Certificate of Analysis provided. Full traceability from raw materials to finished product ensures consistent quality standards.
This is a chemically modified form of hyaluronic acid where acetyl groups are introduced to replace some hydroxyl groups. This modification gives the molecule both water-loving (hydrophilic) and oil-loving (lipophilic) properties—a key advantage over conventional water-soluble HA.
The primary differences include:
· Amphiphilic structure: Works in both water and oil phases
· Enhanced enzyme resistance: 13× more resistant to hyaluronidase degradation
· Deeper penetration: Reaches up to 100 μm versus 50 μm for standard HA
· Superior skin affinity: Longer retention on skin surface even after washing
· Oil-phase stability: No precipitation in oil-based formulations
End consumers benefit from:
· Long-lasting hydration lasting up to 72 hours
· Improved skin elasticity and suppleness
· Enhanced barrier repair and protection
· Reduced dryness and roughness
· Visible improvement in skin texture
Yes. Our product meets FDA, ISO, cGMP, Halal, REACH, and COSMOS certifications, ensuring safety and regulatory compliance across global markets. It has demonstrated excellent tolerability profiles suitable for sensitive skin applications.
Absolutely. We provide customized specifications to match your target:
· Skin feel requirements
· Absorption rate preferences
· Formulation stability needs
· Specific application performance criteria
Products are available in powder or solution form, packaged in moisture-proof containers. We offer options from small-scale R&D quantities (100g) to industrial-scale volumes (1kg, 5kg, 25kg). Custom packaging available upon request.
MOQ depends on packaging type and specifications. Contact our sales team for specific requirements and pricing for your target order volume.
Whether you are developing next-generation serums, advanced moisturizers, or medical-grade skincare products, our AcHA delivers the performance differentiation your brand needs.
Contact us today to:
· Request free product samples
· Discuss custom specifications
· Receive technical documentation (TDS, COA, SDS)
· Get quotation for your order volume
With 28+ years of dedicated HA expertise, we are your reliable partner for high-performance cosmetic ingredients.
Last updated: 2026| © Shandong Runxin Biotechnology Co., Ltd. All rights reserved.
