With over 28 years of expertise in hyaluronic acid innovation, Runxin Biotech has developed Acetylated Sodium Hyaluronate—a next-generation derivative with both lipophilic and hydrophilic properties. This breakthrough ingredient overcomes the limitations of traditional hyaluronic acid, offering deeper skin penetration, stronger stability, and compatibility with oil-based formulations.
However, when customers integrate Acetylated Sodium Hyaluronate into their cosmetic, skincare, or medical formulations, several technical questions often arise. Below, we address some of the most common concerns and share practical solutions.
1. Why does hyaluronic acid sometimes precipitate in oil-based formulations?
Traditional HA is only water-soluble. Acetylated Sodium Hyaluronate, with its lipophilic modification, solves this issue by remaining stable in oil phases without precipitation, ensuring smooth and uniform product texture.
2. How can I ensure maximum skin penetration for long-lasting hydration?
Choose molecular weights optimized for deep penetration. Our Acetylated Sodium Hyaluronate (20,000–50,000 Da) reaches up to 100 μm into the skin, compared to only 50 μm for standard HA.
3. What causes hyaluronic acid degradation over time in formulations?
Hyaluronidase enzymes can break down HA, reducing efficacy. Our acetylated version is 13× more resistant to hyaluronidase, extending shelf life and performance in end products.
4. Is it suitable for both oil-based and water-based products?
Yes. Its amphiphilic nature allows it to be used in creams, lotions, serums, sunscreens, and even medical oil-based dressings without compatibility issues.
5. Can I customize the molecular weight or acetylation degree for my formula?
Absolutely. We provide customized specifications to match your target skin feel, absorption rate, and formulation stability needs.
6. How should it be incorporated into the production process?
For water-based formulas, dissolve it in the aqueous phase. For oil-based products, blend it with the oil phase to fully leverage its lipophilic property.
7. Is it safe for sensitive skin products?
Yes. It meets FDA, ISO, cGMP, Halal, REACH, and COSMOS certifications, ensuring safety and regulatory compliance.
Acetylated Sodium Hyaluronate is not just an ingredient—it’s a formulation game-changer that enhances product stability, efficacy, and sensory appeal.
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