Sodium Hyaluronate Single-Crosslinked | Runxin Verified Purity Global Supply

Manufacturer Profile: Runxin – Advanced HA Innovation Since 1998

Runxin brings 28 years of specialized expertise in molecular modification technologies for advanced hyaluronic acid derivatives. Our state-of-the-art modification facilities maintain comprehensive international certifications including cGMP, ISO9001, ISO22000, ISO13485, HACCP, HALAL, and FSSC22000, with dedicated focus on acetylated HA development. Serving innovative cosmetic, pharmaceutical, and dermal delivery companies across 70+ countries, we combine proprietary acetylation technology with rigorous quality control to deliver acetylated sodium hyaluronate with enhanced functionality and proven performance.

Product Overview: Acetylated Sodium Hyaluronate
Runxin's Acetylated Sodium Hyaluronate represents a scientific breakthrough through controlled introduction of acetyl groups to the hyaluronic acid molecule. This advanced modification creates an amphiphilic polymer that significantly enhances lipid compatibility and skin adhesion while maintaining excellent water-binding capacity. Available in various acetylation degrees (80-95%) and molecular weights (50,000-2,000,000 Da), our product delivers superior skin penetration and prolonged hydration effects, making it ideal for advanced skincare formulations requiring enhanced bioavailability and long-lasting efficacy.

Key Advantages

• Enhanced Skin Adhesion: Acetyl groups dramatically improve substantivity to skin

• Superior Penetration: Balanced lipid-water affinity enables efficient skin barrier transit

• Extended Hydration: Modified structure resists enzymatic degradation for prolonged effects

• Versatile Compatibility: Effective in both aqueous and lipid-based formulations

• Synergistic Enhancement: Improves performance of co-formulated active ingredients

Technical Specifications

• Appearance: White to off-white free-flowing powder

• Acetylation Degree: 80-95%

• Molecular Weight: 50,000-2,000,000 Da (customizable)

• Purity: ≥93% (HPLC)

• Loss on Drying: ≤8%

• pH (1% solution): 5.8-6.8

• Viscosity (1% solution): 150-2,500 mPa·s

• Protein Content: ≤0.04%

• Heavy Metals: ≤4 ppm

• Microbiological Profile:

• Total Plate Count: <100 CFU/g

• Yeast & Mold: <15 CFU/g

• E. coli: Absent in 10g

• Salmonella: Absent in 25g

• Solubility: Excellent in water, dispersible in oils

• Certifications: cGMP, ISO9001, ISO22000, ISO13485, HACCP, HALAL, FSSC22000

Applications

• Advanced anti-aging serums with enhanced penetration

• Lipid-based skincare formulations

• Targeted dermal delivery systems

• Long-lasting moisturizing products

• Professional aesthetic treatments

• Premium cosmetic preparations

FAQs About Acetylated Sodium Hyaluronate

1. What makes acetylated HA more effective than standard hyaluronic acid?
   Acetylated HA's unique amphiphilic nature allows it to penetrate the skin's lipid barrier more effectively, resulting in 3-5 times longer skin residence time, significantly improved moisturization duration, and enhanced delivery of active ingredients compared to conventional hyaluronic acid.

2. How does the acetylation process affect HA's molecular structure and safety?
   Our controlled acetylation process specifically modifies hydroxyl groups while preserving HA's fundamental structure, ensuring maintained biocompatibility and safety. The process is rigorously monitored under cGMP, ISO9001, ISO22000, ISO13485, HACCP, HALAL, and FSSC22000 standards to guarantee product safety and consistency.

3. Can acetylated HA be used in sensitive skin formulations?
   Yes, acetylated HA demonstrates excellent skin compatibility and is particularly suitable for sensitive skin due to its enhanced skin barrier integration and reduced potential for rapid dehydration. Clinical studies show improved tolerance compared to some conventional humectants.

4. What is the ideal usage percentage in different cosmetic formulations?
   Recommended usage is 0.1-2.0% depending on formulation goals. For intensive treatments: 1.0-2.0%, daily care products: 0.2-1.0%, cleansers: 0.1-0.5%. The modified structure provides efficacy at lower concentrations than standard HA.

5. How does acetylated HA perform in stability testing?
   Comprehensive stability testing under ICH guidelines demonstrates excellent thermal stability, pH tolerance (4.0-8.0), and compatibility with common cosmetic preservatives. The acetylated structure shows enhanced resistance to enzymatic degradation compared to native HA.

Why Choose Runxin for Acetylated Sodium Hyaluronate

• 28 Years of Modification Expertise: Advanced molecular engineering since 1998

• Precision Acetylation Technology: Controlled modification for consistent quality

• Comprehensive Quality Assurance: Full certification under cGMP, ISO9001, ISO22000, ISO13485, HACCP, HALAL, and FSSC22000

• Customization Flexibility: Tailored acetylation degrees and molecular weights

• Technical Innovation: Continuous development of advanced HA derivatives

Partner with HA Modification Specialists
Choose Runxin for your acetylated sodium hyaluronate requirements and leverage our 28 years of molecular modification expertise. Contact us today to request samples, technical data, or discuss your specific formulation needs. Experience the advanced performance of acetylated hyaluronic acid from an industry pioneer committed to innovation and quality excellence.