800 Da Sodium Hyaluronate
RUNXIN BIOTECH
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Hyaluronic acid (HA) is a naturally occurring glycosaminoglycan found throughout the human body, renowned for its exceptional water-binding capacity—retaining up to 1,000 times its weight in water. However, not all hyaluronic acid is created equal. The molecular weight of HA determines its biological behavior, penetration capability, and functional benefits.
Oligo hyaluronic acid (also called oligomeric HA or ultra-low molecular weight HA) refers to HA fragments with a molecular weight below 10,000 Daltons (10 kDa). Unlike high-molecular-weight HA (HMW-HA, >500 kDa) that sits on the skin's surface to create a moisturizing film, oligo HA is small enough to penetrate deep into skin layers and be absorbed through the gastrointestinal tract when taken orally.
Understanding the differences between HA molecular weight grades is critical for selecting the right ingredient foryour application:
HA Grade | Molecular Weight Range | Skin Penetration Depth | Primary Functions |
High Molecular Weight | >500 kDa | Stratum corneum (surface) | Surface moisturizing, film-forming, barrier protection |
Medium Molecular Weight | 100-500 kDa | Upper epidermis | Skin smoothing, moderate hydration, texture improvement |
Low Molecular Weight | 10-100 kDa | Lower epidermis | Enhanced hydration, mild anti-inflammatory effects |
Oligo HA | <10 kDa | Dermis + systemic absorption | Deep tissue hydration, collagen synthesis stimulation, oral bioavailability, cellular repair |
Oligo hyaluronic acid exhibits unique biological activities that distinguish it from larger HA molecules:
Deep Skin Penetration: Studies using rhenium-tricarbonyl labeling and confocal microscopy have demonstrated that HA molecules <10 kDa can penetrate up to 100 µm into the skin, reaching the viable epidermis and dermis layers. Research published in Biomolecules (2025) confirmed that 2 kDa HA distributed heterogeneously within keratinocyte extracellular spaces and showed uniform distribution in fibroblasts.
Oral Bioavailability: Unlike HMW-HA that breaks down in the digestive tract, oligo HA is absorbed intact through the intestinal epithelium, reaching systemic circulation and exerting benefits in joints, eyes, and internal organs.
Enhanced Biological Activity: Oligo HA interacts with specific cellular receptors (CD44, RHAMM) to trigger signaling pathways involved in cell proliferation, collagen synthesis, and tissue repair—activities not observed with larger HA molecules.
At Runxin Biotech, we produce oligo hyaluronic acid using proprietary enzymatic cleavage technology, ensuring precise molecular weight control and consistent batch-to-batch quality.
All our oligo HA grades meet or exceed industry standards:
Parameter | Specification |
Appearance | White, odorless powder |
Assay (Hyaluronic Acid) | ≥98% |
Glucuronic Acid Content | ≥46% |
pH (0.1% aqueous solution) | 5.0-7.0 |
Loss on Drying | ≤10.0% |
Protein Content | ≤0.05% |
Heavy Metals (as Pb) | ≤20 ppm |
Arsenic | ≤2 ppm |
Total Aerobic Count | <100 cfu/g |
Mold & Yeast | <20 cfu/g |
Pathogens (S. aureus, E. coli, P. aeruginosa) | Negative |
We offer four standardized oligo HA grades with precise molecular weight control (±5% tolerance, compared to the industry standard ±15%):
Product Grade | Molecular Weight Range | Penetration Profile | Recommended Applications |
RX-OLIGO-1K | 400-1,000 Da | Deep dermal penetration + systemic absorption | Oral supplements, advanced serums, pharmaceutical research |
RX-OLIGO-3K | 1,000-3,000 Da | Full epidermal + upper dermal penetration | Anti-aging creams, eye care, sensitive skin formulations |
RX-OLIGO-5K | 3,000-5,000 Da | Mid-epidermal to dermal junction | Moisturizing lotions, facial masks, after-sun repair |
RX-OLIGO-10K | 5,000-10,000 Da | Lower epidermal penetration | Everyday skincare, hair care products, body lotions |
Custom molecular weight grades are available for specialized applications—contact our technical team to discuss your requirements.
Oligo hyaluronic acid's unique properties make it versatile across multiple industries:
Oligo HA has transformed modern skincare by delivering hydration beyond the surface:
· Deep Moisturizing Serums: 0.1-0.3% concentration of RX-OLIGO-1K or 3K provides 6-7 times longer-lasting hydration compared to regular HA, as shown in 28-day clinical studies with 22 participants.
· Anti-Aging Formulations: Oligo HA stimulates fibroblast activity and collagen synthesis, reducing wrinkle depth by up to 23% after 8 weeks of twice-daily application (as demonstrated in placebo-controlled clinical trials).
· Sensitive Skin & Barrier Repair: The low molecular weight allows gentle penetration without irritation, making it ideal for products targeting rosacea, post-procedure care, and compromised skin barriers.
· Hair & Scalp Care: Penetrates hair follicles to improve scalp hydration and strengthen hair from the root.
Formulation Tip: Oligo HA works synergistically with niacinamide, vitamin C, and peptides. For best results, use at pH 5-6 and avoid heating above 40°C during manufacturing.
The oral bioavailability of oligo HA opens new possibilities in functional nutrition:
· Joint Health Supplements: 50-200 mg daily dosage supports joint lubrication and reduces inflammation, with studies showing improved mobility in osteoarthritis patients after 12 weeks.
· Skin Beauty From Within: Oral oligo HA increases skin hydration and elasticity by boosting endogenous HA production, with effects visible after 4-6 weeks of supplementation.
· Eye Health: Supports tear film stability and reduces dry eye symptoms when used in oral or ophthalmic formulations.
Oligo HA can be incorporated into various food products:
· Functional waters and enhanced beverages
· Yogurts and dairy products
· Protein bars and nutritional supplements
· Confectionery and baked goods
Its neutral taste and excellent water solubility make it easy to formulate into food matrices without affecting product texture or flavor.
Oligo HA is an active area of pharmaceutical research:
· Wound Healing Dressings: Promotes angiogenesis and accelerates tissue repair
· Drug Delivery Systems: Used as a targeting ligand for CD44-overexpressing cancer cells
· Ophthalmic Solutions: Improves ocular bioavailability of active ingredients
Unlike manufacturers using harsh acid hydrolysis that can damage HA molecular structure and reduce biological activity, Runxin uses a proprietary enzymatic cleavage process:
Parameter | Enzymatic Cleavage (Runxin) | Acid Hydrolysis |
Molecular Integrity | Preserves natural structure | Breaks down randomly |
Activity Retention | >95% biological activity | 60-75% activity retention |
Molecular Weight Control | ±5% tolerance | ±15% tolerance |
Color & Purity | Pure white, no discoloration | Slight yellowing possible |
Environmental Impact | Mild, eco-friendly process | Harsh chemicals, higher waste |
Our enzymatic process uses recombinant hyaluronidase enzymes that precisely cut HA molecules at specific sites, resulting in consistent, high-activity oligo HA with minimal batch-to-batch variation.
We understand that molecular weight is the most critical parameter for oligo HA performance. That's why we invest in advanced GPC (Gel Permeation Chromatography) testing for every batch, ensuring our ±5% molecular weight tolerance is consistently met. This precision means your formulations will deliver predictable, reproducible results every time.
Runxin Biotech operates under ISO 9001 and ISO 22000 certified quality management systems. Our production facility is GMP-compliant, and every batch undergoes rigorous testing including:
· Molecular weight verification
· Purity and impurity testing
· Microbial analysis
· Heavy metal screening
· Stability testing
We maintain full traceability from raw material sourcing to finished product, providing complete transparency for your quality assurance needs.
· Flexible MOQs: Starting from 1 kg for standard grades, with no upper limit for bulk orders
· Packaging Options: 1 kg foil bags, 5 kg drums, 25 kg fiber drums, or custom packaging to meet your requirements
· Logistics Support: Experienced international shipping team handling documentation, customs clearance, and cold chain logistics when needed
· Technical Support: Our in-house R&D team provides formulation guidance, troubleshooting, and custom product development support
Runxin oligo hyaluronic acid is certified for global markets:
· ISO 9001: Quality management system certification
· ISO 22000: Food safety management system certification
· HALAL: Islamic dietary law compliance
· GMP: Good Manufacturing Practice certification
· REACH: EU Registration, Evaluation, Authorization and Restriction of Chemicals compliance
We provide full documentation including Technical Data Sheets (TDS), Material Safety Data Sheets (MSDS), Certificate of Analysis (COA), and certification documents with every shipment.
· For deep-penetrating serums and oral supplements: Choose RX-OLIGO-1K or 3K
· For everyday moisturizers and anti-aging creams: RX-OLIGO-5K or 10K
· For hair care and body products: RX-OLIGO-10K is most cost-effective
· Contact our technical team for personalized recommendations based on your specific formulation goals
Oligo HA dissolves much faster in water than high-molecular-weight HA. It typically dissolves completely within 5-10 minutes at room temperature with moderate stirring, compared to 30-60 minutes for HMW-HA. It also produces less viscous solutions, making it easier to incorporate into lightweight formulations.
Store in a cool, dry place away from direct sunlight, in sealed original packaging. Under recommended storage conditions, the shelf life is 24 months from the date of manufacture.
Our standard MOQ is 1 kg for all standard grades. Custom grades may require higher MOQs depending on production complexity—contact us for details.
Yes! We offer custom oligo HA grades with specific molecular weight ranges for specialized applications. Our R&D team can work with you to develop the exact grade you need for your formulation.
Experience the difference of precision-engineered oligo hyaluronic acid from Runxin Biotech.
· Request a Free Sample: Test our oligo HA in your formulations
· Download Technical Data Sheet: Get detailed specifications and application guidelines
· Speak to Our Technical Team: Discuss your specific requirements and get formulation support
Contact us today at sales@runxinbiotech.com or fill out our online inquiry form. Our team typically responds within 24 hours during business days.
Runxin Biotech—Your trusted partner for high-quality hyaluronic acid raw materials.
